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International Foundation for Optic Nerve Disease

P. O. Box 777, Cornwall NY 12518, USA
Email: IFOND@aol.com
Phone [g voice]: 6572067250

 

 ^ EDRF endothelium derived relaxation factor Nitric Oxide. Refers to one of its many effects. This one on blood vessel and bronchial smooth muscle.

Wikipedia

 ^ EGR1 or Early Growth Response 1 is a transcription factor gene which may play roles in cancer supression, apoptosis, eye growth, brain plasticity and learning.

Wikipedia

OMIM 128990

Entrez GeneID 1958

 ^ EGR2 or Early Growth Response 2 is a transcription factor gene which may play roles in myelin formation and cancer supression. Mutations here cause autosomal dominant Charcot-Marie-Tooth disease, type 1.

Wikipedia

OMIM 129010

Entrez GeneID 1959

 ^ EGR3 or Early Growth Response 3 is a transcription factor gene.

From Entrez Gene: "The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also plays a role in muscle development." It is involved in circadian rhythm cycling signaled from photoreceptors and transmitted to the suprachiasmatic nucleus via the retinohypothalamic tract.

Wikipedia

Entrez GeneID 1960

OMIM 602419

 ^ Electron Paramagnetic Spectroscopy (EPR)A technique for studying chemicals with unpaired electrons such as free radicals. It is used to "spin-label" specific biological cell sites for study.

Wikipedia

 ^ Electron Transport Chain An organized process of oxidation (stealing electrons) used to create a proton gradient across the inner mitochondrial membrane which in turn is used for phosphorylation of ADP to ATP, the energy currency of the cell. NADH, the driver of the process, is produced in the preceeding glycolysis and tricarboxylic acid cycle. It is oxidized and O2 is ultimately reduced to H2O. Defects in this process may lead to various diseases including optic neuropathies. See Complexes of the electron transport chain of oxidative phosphorylation.

Wikipedia

 ^ Electroretinogram (ERG)Measurement of the electrical response of the retina to light stimulation.

Webvision Clinical ERG

Medline Plus patient information

Wikipedia

 ^ Embryology The study of the development of organisms, organs and tissues. At its fundamental level it seeks to understand what drives cells to organize and differentiate into tissue types and organs. Insights from this discipline may unlock the keys to tissue specificity of genetic mutations and variability in penetrance of optic nerve disease.

Wikipedia

 ^ Endothelium The inner lining of blood vessels.

Wikipedia

 ^ Enzyme A protein or protein complex which controls the rate of a specific chemical reaction in the cell.

Wikipedia

 ^ Epigenetic Change in gene function other than by a change in genetic code sequence.

Bob Weinhold. Epigenetics: The Science Of Change. Environmental Health Perspectives Volume 114, Number 3, March 2006

Wikipedia

 ^ Erythropoietin A glycoprotein hormone cytokine important in blood formation. It is being trialed for neuroprotection in neural ischaemic injury and glaucoma.

L Torup. Neuroprotection with or without erythropoiesis; sometimes less is more. British Journal of Pharmacology (2007) 151, 1141-1142

Zhong L, Bradley J, Schubert W, Ahmed E, Adamis AP, Shima DT, Robinson GS, Ng YS. Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1212-8. PMID 17325165

Wikipedia neuroprotection

Wikipedia

 ^ Ethambutol An anti tuberculosis drug known to cause toxic optic nerve disease.

Wikipedia

 ^ Excitotoxicity A set of conditions damaging to the cell resulting from excitatory neurotransmission. Glutamate, the predominant excitatory neurotransmitter in the eye in certain conditions may begin a cascade of events leading to cell death.

Wikipedia

 ^ Exon The sequences in gene DNA or RNA coding for proteins or non-coding RNA as opposed to the interspersing non expressing Introns. Compare: Codon

Wikipedia

 ^ Extrastriate cortex is the part of the occipital cortex of mammals' brains adjacent to the striate cortex (or primary visual cortex).

Wikipedia

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The International Foundation for Optic Nerve Disease
P. O. Box 777, Cornwall NY 12518, USA.
Phone [g voice]: 6572067250
Email: ifond@aol.com
Web site: http://www.ifond.org/


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