IFOND research | LHON treatment prospects | Mitochondrial Genome Editing | COVID-19 and LHON | LHON talks | Pay it forward | Mitochondrial Regulation | Avoid BAK eye drop preservative, etc. | We experiment with cigarette smoke so you need not. | Viral vector trials | EPI-743 LHON trials | Idebenone LHON trialsDigests: NEI News | Mitochondrial Disease News LHON | ARVO Journals LHON | PubMed LHON | Europe PMC LHON | MRC-MBU features
Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
The authors of a study on the most commonly used eye drop preservative, Benzalkonium Chloride [BAK], conclude: "Prescribing BAK-containing eye drops should be avoided in patients with mitochondrial deficiency, including LHON patients, LHON carriers, and possibly primary open-angle glaucoma patients." Because: " Benzalkonium chloride inhibits mitochondria of human corneal epithelial cells and cells bearing LHON mutations at pharmacologically relevant concentrations, and we suggest this is the basis of BAK's ocular toxicity. "
A more recent study also implicates other quaternary ammonium salt [QUATS] antiseptics, specifically cetylpyridinium chloride [CPC]. The authors say: "Mitochondrial inhibition in vitro occurred at a CPC concentration that may be relevant to human exposures. The antiestrogenic activity of CPC, BAK, rotenone, and triclosan may be related to their mitochondrial inhibitory activity. Our findings support the need for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, including CPC and BAK."
Benzalkonium chloride, cetylpyridinium chloride and triclosan are commonly used as antiseptics and preservatives in many skin creams, ointments and personal care products.
It is highly recommended that those with a family history of optic nerve or retinal disease enquire themselves and with their health professional about possible eye toxicity before being exposed to any drug or substance.
The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Sandipan Datta; Christophe Baudouin; Francoise Brignole-Baudouin; Alexandre Denoyer; Gino A. Cortopassi. Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2406-2412. doi:10.1167/iovs.16-20903
In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride Sandipan Datta,1 Guochun He,2 Alexey Tomilov,1 Sunil Sahdeo,1 Michael S. Denison,2 and Gino Cortopassi1. Environ Health Perspect; DOI:10.1289/EHP1404
Listing for Benzalkonium Chloride in Household Products Database from US Department of Health and Human Services.
Listing for cetylpyridinium chloride in Household Products Database from US Department of Health and Human Services.
Listing for triclosan in Household Products Database from US Department of Health and Human Services.
The International Foundation for
Optic Nerve Disease
P. O. Box 777, Cornwall NY 12518, USA.
Web site: http://www.ifond.org/
IFOND is registered service mark of
The International Foundation for Optic Nerve Disease, est. October 1995.
Copyright 1999-2020, International Foundation for Optic Nerve Disease.
The information contained on this website should not be considered medical guidance or professional advice. IFOND is not responsible for errors or omissions in information provided on this site or actions resulting from its use. IFOND does not publish all information from all available sources on optic nerve disease. IFOND is not responsible for the validity of the studies or reviews nor is it an advocate of studies or reviews mentioned on or linked from the IFOND web site. IFOND does not endorse or recommend participation in any particular clinical trial or treatment protocol which may be mentioned on this site. Direct any questions concerning your personal health to your appropriate health care professional.